The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity
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چکیده
منابع مشابه
The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity.
IGF-1 and growth hormone (GH) interact with insulin to modulate its control of carbohydrate metabolism. A new study (see the related article beginning on page 96) shows that blocking the effect of GH in the presence of low serum IGF-1 concentrations enhances insulin sensitivity.
متن کاملThe relative roles of growth hormone and IGF - 1 in controlling insulin sensitivity
25 shown to contain an androgen receptor ligand (Table 1). However, the systematic study by Huang et al. reveals that a single compound found in both YZH and Yin Chin (6,7-dimethylesculetin) is sufficient to activate CAR and induce bilirubin clearance. This is a wonderful example of knowledge gained by applying the Western scientific method to an Eastern herbal remedy. It will be very exciting ...
متن کاملInsulin-like growth factor 1 (IGF-1): a growth hormone.
AIM To contribute to the debate about whether growth hormone (GH) and insulin-like growth factor 1 (IGF-1) act independently on the growth process. METHODS To describe growth in human and animal models of isolated IGF-1 deficiency (IGHD), such as in Laron syndrome (LS; primary IGF-1 deficiency and GH resistance) and IGF-1 gene or GH receptor gene knockout (KO) mice. RESULTS Since the descri...
متن کاملInsulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-1 in insulin resistance.
Liver IGF-1 deficient (LID) mice demonstrate a 75% reduction in circulating IGF-1 levels and a corresponding fourfold increase in growth hormone (GH) levels. At 16 weeks of age, LID mice demonstrate, using the hyperinsulinemic-euglycemic clamp, insulin insensitivity in muscle, liver, and fat tissues. In contrast, mice with a gene deletion of the acid-labile subunit (ALSKO) demonstrate a 65% red...
متن کاملEffect of Six Months of Aerobic Exercise on Serum Levels of Insulin, Growth Hormone and Insulin-Like Growth Hormone 1 in Sedentary Obese Women
ABSTRACT Background and Objectives: Inactivity, obesity and hormone disorders can lead to various diseases in obese and non-athletic individuals. The objective of this study was to investigate effects of six months of aerobic exercise on serum levels of insulin, growth hormone (GH) and insulin-like growth hormone 1 (IGF-1) in sedent...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2004
ISSN: 0021-9738
DOI: 10.1172/jci200420660